Simple evolutionary pathways to complex proteins

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Simple evolutionary pathways to complex proteins.

A recent paper in this journal has challenged the idea that complex adaptive features of proteins can be explained by known molecular, genetic, and evolutionary mechanisms. It is shown here that the conclusions of this prior work are an artifact of unwarranted biological assumptions, inappropriate mathematical modeling, and faulty logic. Numerous simple pathways exist by which adaptive multi-re...

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ژورنال

عنوان ژورنال: Protein Science

سال: 2005

ISSN: 0961-8368,1469-896X

DOI: 10.1110/ps.041171805